{"id":3869,"date":"2023-02-18T13:50:03","date_gmt":"2023-02-18T04:50:03","guid":{"rendered":"https:\/\/blackfire.work\/?p=3869"},"modified":"2024-04-14T16:26:32","modified_gmt":"2024-04-14T07:26:32","slug":"%e3%81%86%e3%81%a4%e7%97%85%e5%bc%95%e3%81%8d%e8%b5%b7%e3%81%93%e3%81%99%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%ef%bc%83%e3%82%b3%e3%83%ad%e3%83%8a%ef%bc%92","status":"publish","type":"post","link":"https:\/\/blackfire.work\/?p=3869","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u3046\u3064\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u3066\u307f\u305f\uff03\u30b3\u30ed\u30ca\uff12\uff10\uff11\uff19"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u3046\u3064\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u3066\u307f\u305f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305a\u4e3b\u6210\u5206\u306e\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f53\u5185\u3067\u9178\u5316\u3059\u308b\u3068\u6700\u7d42\u7684\u306b\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u306a\u3063\u3066\u4f53\u5185\u306b\u84c4\u7a4d\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -internal\" data-type=\"type1\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">\u3042\u308f\u305b\u3066\u8aad\u307f\u305f\u3044<\/span>\n\t\t\t\t\t<div class=\"p-blogCard__thumb c-postThumb\"><figure class=\"c-postThumb__figure\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/blackfire.work\/wp-content\/uploads\/2022\/11\/pexels-photo-3781550-300x200.jpeg\" alt=\"\" class=\"c-postThumb__img u-obf-cover\" width=\"320\" height=\"180\"><\/figure><\/div>\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/blackfire.work\/?p=3290\">\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u81ed\u306e\u539f\u56e0\u3092\u89e3\u660e\u3057\u305f\u30c4\u30a4\u30c3\u30bf\u30e9\u30fc\u304c\u767b\u5834\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u7d0d\u5f97<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">https:\/\/twitter.com\/sarvadarsana\/status\/1608019059085565953?s=20 https:\/\/twitter.com\/sarvadarsana\/status\/1608019064366202881?s=20 https:\/\/twitter.com\/sarvada&#8230;<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306f\u7a7a\u6c17\u4e2d\u306b\u304a\u3044\u3066\u9178\u5316\u306b\u3088\u308b\u52a3\u5316\u3092\u53d7\u3051\u307e\u3059\u3002\u9ad8\u6e29\u3084\u9178\u7d20\u3078\u306e\u66b4\u9732\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u305f\u308a\u3001\u9178\u5316\u9632\u6b62\u5264\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u3067\u3001PEG\u306e\u52a3\u5316\u3092\u5236\u9650\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306f\u4fdd\u7ba1\u4e2d\u306b\u52a0\u6c34\u5206\u89e3\u3084\u52a3\u5316\u3092\u8d77\u3053\u3055\u305a\u3001\u30ab\u30d3\u3082\u767a\u751f\u3057\u307e\u305b\u3093\u3002\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306f\u30d5\u30a7\u30ce\u30fc\u30eb\u3068\u9069\u5408\u305b\u305a\u3001\u4ed6\u306e\u9632\u8150\u5264\u306e\u6297\u83cc\u4f5c\u7528\u3092\u963b\u5bb3\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306f\u30da\u30cb\u30b7\u30ea\u30f3\u3084\u30d0\u30b7\u30c8\u30e9\u30b7\u30f3\u3092\u77ed\u6642\u9593\u3067\u4e0d\u6d3b\u6027\u5316\u3057\u3001\u30bd\u30eb\u30d3\u30c8\u30fc\u30eb\u3001\u30bf\u30f3\u30cb\u30f3\u9178\u3001\u30b5\u30ea\u30c1\u30eb\u9178\u3068\u306f\u9069\u5408\u3057\u307e\u305b\u3093<sup>3<\/sup>\u3002<\/p>\n<cite>https:\/\/www.sigmaaldrich.com\/JP\/ja\/technical-documents\/technical-article\/materials-science-and-engineering\/drug-delivery\/polyethylene-glycol-selection-guide-jp<\/cite><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u3053\u3068\u306f\u8840\u4e2d\u306e\u9178\u7d20\u3068\u7d50\u5408\u3059\u308b\u3068\u9178\u5316\u3059\u308b\u306e\u3067\u306f\uff1f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u81ea\u4f53\u306f\u8133\u306e\u7d30\u80de\u58c1\u3092\u518d\u751f\u3059\u308b\u3068\u306e\u7814\u7a76\u7d50\u679c\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u308c\u306f\u9178\u5316\u3057\u306a\u3044\u524d\u63d0\u3067\u306e\u8a71\u306a\u306e\u3067\u9577\u671f\u7684\u306b\u8133\u5185\u306b\u904b\u3070\u308c\u305f\u9178\u7d20\u3068\u7d50\u5408\u3057\u3066\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306b\u5909\u5316\u3002\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u81ea\u4f53\u3082\u5287\u7269\u3060\u304c\u3001\u305d\u306e\u5f8c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u306a\u3069\u69d8\u3005\u306a\u4eba\u4f53\u306b\u6709\u5bb3\u306a\u7269\u8cea\u306b\u5909\u5316\u3059\u308b\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3084\u305d\u306e\u8a98\u5c0e\u4f53\u3092\u9178\u7d20\u96f0\u56f2\u6c17\u4e2d,100W\u9ad8\u5727\u7d2b\u5916\u30e9\u30f3\u30d7\u3092\u7528\u3044\u3066\u5185\u90e8\u7167\u5c04\u3042\u308b\u3044\u306f\u5916\u90e8\u7167\u5c04\u3057\u305f\u3002\u305d\u306e\u7d50\u679c, <span class=\"swl-marker mark_orange\">\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306e\u5834\u5408\u306b\u306f\u8131\u6c34\u53cd\u5fdc\u751f\u6210\u7269\u3068\u3057\u3066,\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9,\u305d\u306e\u4e8c\u6b21\u53cd\u5fdc\u751f\u6210\u7269\u3068\u3057\u3066,\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3001\u30a8\u30c1\u30ec\u30f3\u30a2\u30bb\u30bf\u30fc\u30eb,\u9162 \u9178 \u30a8\u30c1\u30eb,\u70ad \u7d20-\u70ad \u7d20\u7d50\u5408\u306e\u5207\u65ad\u53cd\u5fdc\u751f\u6210\u7269 \u3068\u3057\u3066,\u30e1 \u30bf\u30ce\u30fc\u30eb<\/span>\u304c,\u307e \u305f,\u30d7 \u30ed\u30d4 \u30ec\u30f3\u30b0 \u30ea\u30b3\u30fc\u30eb\u306e\u5834\u5408\u306b\u306f \u30a2\u30bb\u30c8\u30f3,\u305d\u306e\u30b1\u30bf\u30fc\u30eb,\u30a4\u30bd\u30d7\u30ed\u30d4\u30eb\u30a2\u30eb\u30b3\u30fc\u30eb\u306a\u3069\u304c\u305d\u308c\u305e\u308c\u5f97\u3089\u308c\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9,\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306e\u30aa\u30ad\u30b7\u57fa\u3092\u30a2\u30bb\u30bf\u30fc\u30eb\u307e \u305f\u306f\u30a8\u30fc\u30c6\u30eb\u5316\u306b\u3088\u3063\u3066\u4fdd\u8b77\u3057\u305f\u3082\u306e\u306f\u3044\u305a\u308c\u3082\u5149\u9178\u5316\u3055\u308c,\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u30a8\u30c1\u30ec\u30f3\u30a2\u30bb\u30bf\u30fc\u30eb\u306e\u5834\u5408\u306b\u306f\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc \u30eb\u30e2\u30ce\u30a2\u30bb\u30c6\u30fc\u30c8\u304c,\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u30e2\u30ce\u30e1\u30c1\u30eb\u30a8\u30fc\u30c6\u30eb,\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u30b8\u30e1\u30c1\u30eb\u30a8\u30fc\u30c6\u30eb\u306e\u5834\u5408\u306b\u306f\u9178\u5316\u5207\u65ad\u53cd\u5fdc\u751f&nbsp;\u6210\u7269 \u3068\u3057\u3066,\u30db \u30eb\u30e0\u30a2\u30eb\u30c7 \u30d2 \u30c9,\u30ae \u9178,\u30ae \u9178 \u30e1\u30c1\u30eb\u306a \u3069\u304c\u5f97 \u3089\u308c \u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<cite>https:\/\/www.jstage.jst.go.jp\/article\/nikkashi1898\/69\/4\/69_4_654\/_pdf\/-char\/ja<\/cite><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u7d2b\u5916\u7dda\u3068\u9178\u7d20\u3067\u3053\u3053\u307e\u3067\u5206\u89e3\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3053\u3067\u6ce8\u76ee\u3057\u305f\u3044\u306e\u304c\u30e1\u30bf\u30ce\u30fc\u30eb<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u3061\u306a\u307f\u306b\u4e0b\u8a18\u306f\u591a\u91cf\u306b\u30e1\u30bf\u30ce\u30fc\u30eb\u3092\u63a5\u7a2e\u3057\u305f\u5834\u5408\u306e\u4e2d\u6bd2\u75c7\u72b6\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u30e1\u30bf\u30ce\u30fc\u30eb\u4e2d\u6bd2\u306f\u3001\u53d6\u308a\u6271\u3044\u6642\u306e\u5438\u5165\u3001\u6545\u610f\u306e\u6442\u53d6\u3001\u8aa4\u98f2\u3084\u591a\u91cf\u306e\u76ae\u819a\u63a5\u89e6\u3067\u8d77\u3053\u308b<sup><a href=\"https:\/\/ja.wikipedia.org\/wiki\/%E3%83%A1%E3%82%BF%E3%83%8E%E3%83%BC%E3%83%AB#cite_note-6\">[6]<\/a><\/sup>\u3002\u30e1\u30bf\u30ce\u30fc\u30eb\u306e<a 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href=\"https:\/\/ja.wikipedia.org\/wiki\/%E3%83%A1%E3%82%BF%E3%83%8E%E3%83%BC%E3%83%AB%E6%AF%92%E6%80%A7#cite_note-Fer2016-3\">[3]<\/a><\/sup>\u3002\u65e9\u671f\u6cbb\u7642\u306b\u3088\u308b\u52b9\u679c\u306f\u3088\u3044<sup><a href=\"https:\/\/ja.wikipedia.org\/wiki\/%E3%83%A1%E3%82%BF%E3%83%8E%E3%83%BC%E3%83%AB%E6%AF%92%E6%80%A7#cite_note-Kr2012-1\">[1]<\/a><\/sup>\u3002\u65e9\u304f\u30661856\u5e74\u306b\u306f\u30e1\u30bf\u30ce\u30fc\u30eb\u6bd2\u6027\u306b\u3064\u3044\u3066\u8a18\u3055\u308c\u3066\u3044\u308b<sup><a href=\"https:\/\/ja.wikipedia.org\/wiki\/%E3%83%A1%E3%82%BF%E3%83%8E%E3%83%BC%E3%83%AB%E6%AF%92%E6%80%A7#cite_note-5\">[5]<\/a><\/sup>\u3002<\/p>\n<cite>https:\/\/ja.wikipedia.org\/wiki\/\u30e1\u30bf\u30ce\u30fc\u30eb\u6bd2\u6027<\/cite><\/blockquote>\n\n\n\n<h2 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class=\"wp-block-paragraph\">560\u4e07\u4eba\u8d85\u304c\u767b\u9332\u3059\u308b\u7c73\u56fd\u9000\u5f79\u8ecd\u4eba\u7701\u306e\u533b\u7642\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u4eba\u306f\u3001\u75c7\u72b6\u304c\u6cbb\u307e\u3063\u305f\u5f8c\u306b\u7cbe\u795e\u7684\u306a\u554f\u984c\u3092\u62b1\u3048\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u3053\u306e\u8abf\u67fb\u306f\u30012022\u5e742\u670816\u65e5\u4ed8\u3051\u306e\u533b\u5b66\u8a8c\u300c\u30d6\u30ea\u30c6\u30a3\u30c3\u30b7\u30e5\u30fb\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30b8\u30e3\u30fc\u30ca\u30eb\u300d\u306b\u63b2\u8f09\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u5171\u8457\u8005\u3067\u3001\u7c73\u30df\u30ba\u30fc\u30ea\u5dde\u306b\u3042\u308b\u30bb\u30f3\u30c8\u30eb\u30a4\u30b9\u30fb\u30ef\u30b7\u30f3\u30c8\u30f3\u5927\u5b66\u81e8\u5e8a\u75ab\u5b66\u30bb\u30f3\u30bf\u30fc\u9577\u306e\u30b8\u30e4\u30c9\u30fb\u30a2\u30eb\u30fb\u30a2\u30ea\u30fc\u6c0f\u306f\u3001\u6b21\u306e\u3088\u3046\u306b\u30b3\u30e1\u30f3\u30c8\u3057\u3066\u3044\u308b\u3002\u300c\u3053\u306e\u56fd\u306f\u3001\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u3068\u30ed\u30c3\u30af\u30c0\u30a6\u30f3\u306e\u6df7\u4e71\u306b\u3088\u308b\u7cbe\u795e\u7684\u554f\u984c\u3092\u62b1\u3048\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3057\u3066\u3057\u307e\u3063\u305f\u4eba\u306f\u3001\u5927\u5909\u306a\u601d\u3044\u3092\u3057\u3066\u3044\u307e\u3059\u300d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2022\u5e746\u670821\u65e5\u4ed8\u3051\u3067\u5b66\u8853\u8a8c\u300cCNS Drugs\u300d\u306b\u63b2\u8f09\u3055\u308c\u305f\u30ec\u30d3\u30e5\u30fc\u8ad6\u6587\u306b\u3088\u308b\u3068\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u4eba\u306e35%\u304c\u3001\u56de\u5fa9\u5f8c\u306b\u3046\u3064\u306e\u75c7\u72b6\u3092\u8a34\u3048\u305f\u3068\u3044\u3046\u3002\u611f\u67d3\u306b\u3088\u3063\u3066\u6570\u65e5\uff5e\u6570\u9031\u9593\u306b\u308f\u305f\u3063\u3066\u65e5\u5e38\u751f\u6d3b\u304c\u596a\u308f\u308c\u305f\u3053\u3068\u306b\u3088\u308b\u7cbe\u795e\u7684\u82e6\u75db\u3082\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u305d\u308c\u3060\u3051\u3067\u306f\u306a\u3055\u305d\u3046\u3060\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3042\u307e\u308a\u77e5\u3089\u308c\u3066\u3044\u306a\u3044\u304c\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u9650\u3089\u305a\u3001\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u5f8c\u306b\u3001\u708e\u75c7\u6027\u5909\u5316\u306a\u3069\u306e\u751f\u7269\u5b66\u7684\u306a\u8981\u56e0\u3067\u3046\u3064\u75c5\u3092\u767a\u75c7\u3059\u308b\u3068\u3044\u3046\u73fe\u8c61\u304c\u3042\u308b\u3002\u305d\u3057\u3066\u3053\u306e\u8ad6\u6587\u3067\u3082\u3001\u4e3b\u306b\u514d\u75ab\u7cfb\u306e\u708e\u75c7\u304c\u3046\u3064\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u304a\u308a\u3001\u30b3\u30ed\u30ca\u60a3\u8005\u306e\u3046\u3064\u3078\u306e\u65e9\u3081\u306e\u30b1\u30a2\u3068\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u91cd\u8981\u3060\u3068\u6307\u6458\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3046\u3064\u306e\u75c7\u72b6\u306f\u901a\u5e38\u3001\u300c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3092\u767a\u75c7\u3057\u3066\u304b\u30892\uff5e3\u30ab\u6708\u5f8c\u306b\u73fe\u308c\u3001\u6570\u30ab\u6708\u9593\u7d9a\u304f\u3088\u3046\u3067\u3059\u3002\u3069\u3093\u306a\u4eba\u304c\u4e00\u6642\u7684\u306a\u75c7\u72b6\u3067\u6e08\u3080\u306e\u304b\u3001\u305d\u308c\u3068\u3082\u9577\u671f\u5316\u3059\u308b\u306e\u304b\u306f\u4e88\u6e2c\u3067\u304d\u307e\u305b\u3093\u300d\u3068\u3001\u7c73\u30c6\u30ad\u30b5\u30b9\u5927\u5b66\u30b5\u30a6\u30b9\u30a6\u30a7\u30b9\u30bf\u30f3\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3046\u3064\u75c5\u7814\u7a76\u30fb\u81e8\u5e8a\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\u306e\u5275\u7acb\u8005\u517c\u30bb\u30f3\u30bf\u30fc\u9577\u3092\u52d9\u3081\u308b\u30de\u30c9\u30a5\u30ab\u30fc\u30fb\u30c8\u30ea\u30d9\u30c7\u30a3\u6c0f\u306f\u8a00\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306b\u3088\u308b\u3046\u3064\u306e\u30ea\u30b9\u30af<\/h2>\n\n\n\n<p class=\"has-swl-pale-01-background-color has-background wp-block-paragraph\">\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3068\u3046\u3064\u75c5\u306e\u95a2\u4fc2\u306f\u4ee5\u524d\u304b\u3089\u6307\u6458\u3055\u308c\u3066\u3044\u305f\u3082\u306e\u306e\u3001\u5e83\u304f\u8a8d\u77e5\u3055\u308c\u3001\u7406\u89e3\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u306f\u3053\u3053\u6570\u5341\u5e74\u306e\u3053\u3068\u3060\u30022016\u5e74\u306b\u533b\u5b66\u8a8c\u300cBrain, Behavior, and Immunity\u300d\u306b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u904e\u53bb30\uff5e180\u65e5\u306e\u9593\u306b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u304b\u304b\u3063\u305f\u4eba\u306f\u3001\u65b0\u305f\u306b\u3046\u3064\u75c5\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u3001\u305d\u3046\u3067\u306a\u3044\u4eba\u3068\u6bd4\u3079\u306657%\u3082\u9ad8\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u4f1d\u67d3\u6027\u5358\u6838\u7403\u75c7\u306e\u539f\u56e0\u3068\u306a\u308b\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u79d1\u306eEB\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u3067\u3082\u3001\u540c\u69d8\u306e\u3053\u3068\u304c\u8d77\u3053\u308a\u3046\u308b\u3068\u5c02\u9580\u5bb6\u306f\u6307\u6458\u3059\u308b\u3002<\/p>\n\n\n\n<p class=\"has-swl-pale-01-background-color has-background wp-block-paragraph\">\u30a2\u30eb\u30fb\u30a2\u30ea\u30fc\u6c0f\u306e\u8abf\u67fb\u3067\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306e\u6700\u521d\u306e\u967d\u6027\u5224\u5b9a\u304b\u308930\u65e5\u5f8c\u306b\u4e0d\u5b89\u75c7\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u306f35%\u3001\u4e00\u6642\u7684\u306a\u3046\u3064\u72b6\u614b\u306b\u9665\u308b\u30ea\u30b9\u30af\u306f39%\u9ad8\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u305d\u308c\u306b\u4f34\u3063\u3066\u6297\u3046\u3064\u5264\u3084\u3001\u7761\u7720\u85ac\u3084\u6297\u4e0d\u5b89\u85ac\u3068\u3057\u3066\u4f7f\u308f\u308c\u308b\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u5411\u7cbe\u795e\u85ac\u306e\u4f7f\u7528\u3082\u5897\u52a0\u3057\u3066\u3044\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307b\u304b\u306b\u3082\u30012022\u5e744\u6708\u53f7\u306e\u533b\u5b66\u8a8c\u300cJournal of Neurology\u300d\u306e\u8abf\u67fb\u3067\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3057\u3066\u304b\u30898\u30ab\u6708\u5f8c\u3082\u75b2\u52b4\u611f\u3092\u8a34\u3048\u308b\u60a3\u8005\u306e\u9593\u3067\u3001\u9ad8\u3044\u30ec\u30d9\u30eb\u306e\u7121\u6c17\u529b\u611f\u3084\u4e0d\u5b89\u611f\u3092\u62b1\u304f\u4eba\u304c\u591a\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u30022022\u5e745\u6708\u53f7\u306e\u533b\u5b66\u8a8c\u300cThe Lancet\u300d\u306b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u306e6\u30ab\u56fd\u3067\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3057\u305f\u304c\u5165\u9662\u306f\u3057\u306a\u304b\u3063\u305f\u60a3\u8005\u306e\u5fc3\u306e\u5065\u5eb7\u72b6\u614b\u3092\u8ffd\u8de1\u3057\u305f\u7d50\u679c\u3001\u56de\u5fa9\u5f8c\u4f55\u30ab\u6708\u3082\u3046\u3064\u75c7\u72b6\u306b\u60a9\u307e\u3055\u308c\u308b\u4eba\u306e\u5272\u5408\u304c\u9ad8\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u7279\u306b\u3001\u30b3\u30ed\u30ca\u3067\u5e8a\u306b\u81e5\u305b\u3063\u3066\u3044\u305f\u4eba\u307b\u3069\u305d\u306e\u50be\u5411\u304c\u9855\u8457\u3060\u3063\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306f\u3069\u306e\u3088\u3046\u306b\u3046\u3064\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u304b<\/h2>\n\n\n\n<p 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class=\"wp-block-heading\">\u30b3\u30ed\u30ca\u5f8c\u3046\u3064\u306b\u306a\u308a\u3084\u3059\u3044\u4eba\u306f\uff1f\u3000\u7537\u5973\u3067\u9055\u3044\u3082<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306f\u6bd4\u8f03\u7684\u65b0\u3057\u3044\u75be\u60a3\u3067\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u554f\u984c\u306b\u95a2\u3059\u308b\u7814\u7a76\u3082\u307e\u3060\u591a\u304f\u306f\u306a\u3044\u304c\u3001\u5c02\u9580\u5bb6\u306f\u3001\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u75c7\u306e\u65e2\u5f80\u6b74\u304c\u3042\u308b\u4eba\u306f\u3001\u30b3\u30ed\u30ca\u5f8c\u3046\u3064\u306b\u304b\u304b\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u8003\u3048\u3066\u3044\u308b\u3002\u300c\u81e8\u5e8a\u306e\u73fe\u5834\u3067\u306f\u3001\u4ee5\u524d\u3046\u3064\u75c5\u306b\u304b\u304b\u3063\u305f\u3053\u3068\u304c\u3042\u308b\u3082\u306e\u306e\u3001\u30b3\u30ed\u30ca\u524d\u306b\u306f\u6539\u5584\u3057\u3066\u3044\u305f\u308a\u3001\u5143\u3005\u305d\u308c\u307b\u3069\u6df1\u523b\u3067\u306f\u306a\u304b\u3063\u305f\u306e\u306b\u3001\u30b3\u30ed\u30ca\u5f8c\u306b\u518d\u3073\u3046\u3064\u75c5\u3092\u767a\u75c7\u3057\u305f\u308a\u3001\u75c7\u72b6\u304c\u60aa\u5316\u3057\u305f\u3068\u3044\u3046\u60a3\u8005\u3055\u3093\u3092\u3088\u304f\u898b\u307e\u3059\u300d\u3068\u30dd\u30c3\u30bf\u30fc\u6c0f\u306f\u8a00\u3046\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307b\u304b\u306b\u3082\u5c0f\u898f\u6a21\u306a\u7814\u7a76\u3060\u304c\u3001\u611f\u67d3\u524d\u304b\u3089\u5f37\u3044\u30b9\u30c8\u30ec\u30b9\u304c\u3042\u3063\u305f\u4eba\u3001\u80a5\u6e80\u3001\u305c\u3093\u305d\u304f\u3001\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u306a\u3069\u306e\u5408\u4f75\u75c7\u3092\u62b1\u3048\u3066\u3044\u305f\u4eba\u3001\u305d\u3057\u3066\u65b0\u578b\u30b3\u30ed\u30ca\u3067\u91cd\u75c7\u5316\u3057\u305f\u4eba\u3082\u3001\u30b3\u30ed\u30ca\u5f8c\u3046\u3064\u306b\u304b\u304b\u308a\u3084\u3059\u3044\u3068\u3044\u3046\u7d50\u679c\u304c\u30012022\u5e741\u6708\u306b\u533b\u5b66\u8a8c\u300cJournal of the Academy of Consultation-Liaison Psychiatry\u300d\u306b\u767a\u8868\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9577\u671f\u306e\u30b3\u30ed\u30ca\u5f8c\u907a\u75c7\u306e\u4e00\u3064\u3068\u3057\u3066\u3046\u3064\u75c5\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002\u3053\u306e\u5834\u5408\u3001\u8a18\u61b6\u529b\u3001\u601d\u8003\u529b\u3001\u96c6\u4e2d\u529b\u306b\u95a2\u3059\u308b\u554f\u984c\u3001\u6c17\u5206\u306e\u5909\u5316\u3001\u75b2\u52b4\u611f\u306e\u307b\u304b\u3001\u85ac\u3084\u304a\u91d1\u306e\u7ba1\u7406\u306b\u5fc5\u8981\u306a\u6574\u7406\u80fd\u529b\u306e\u4f4e\u4e0b\u3068\u3044\u3063\u305f\u72b6\u614b\u304c\u3060\u3089\u3060\u3089\u3068\u7d9a\u304f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c02\u9580\u5bb6\u305f\u3061\u306f\u30b3\u30ed\u30ca\u5f8c\u3046\u3064\u306b\u95a2\u3057\u3066\u660e\u78ba\u306a\u6027\u5dee\u306f\u898b\u3089\u308c\u306a\u3044\u3068\u8a00\u3046\u304c\u30012022\u5e741\u6708\u306b\u533b\u5b66\u8a8c\u300cJournal of Psychiatric 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