{"id":3241,"date":"2023-01-03T21:54:46","date_gmt":"2023-01-03T12:54:46","guid":{"rendered":"https:\/\/blackfire.work\/?p=3241"},"modified":"2023-01-03T21:54:48","modified_gmt":"2023-01-03T12:54:48","slug":"%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e6%8e%a5%e7%a8%ae%e8%80%85%e3%81%8b%e3%82%89%e6%84%9f%e6%9f%93%e3%81%99%e3%82%8b-%e3%83%95%e3%82%a1%e3%82%a4%e3%82%b6%e3%83%bc%e3%82%82%e8%aa%8d%e3%82%81","status":"publish","type":"post","link":"https:\/\/blackfire.work\/?p=3241","title":{"rendered":"\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u304b\u3089\u611f\u67d3\u3059\u308b&#8230;\u30d5\u30a1\u30a4\u30b6\u30fc\u3082\u8a8d\u3081\u305f\u201d\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u201d\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u3066\u307f\u305f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3068\u306f\uff1f<\/h2>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"ja\" dir=\"ltr\">\u30ef\u30af\u30c1\u30f3\u672a\u63a5\u7a2e\u306e\u65b9\u306f\u6e29\u6cc9\u3084\u30b5\u30a6\u30ca\u306f\u63a7\u3048\u305f\u65b9\u304c\u826f\u3044\u3067\u3059\u3002<br>\u63a5\u7a2e\u8005\u306e\u6c57\u3067\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u66dd\u9732\u3057\u3001\u9177\u3044\u3068\u6570\u65e5\u3067\u547c\u5438\u56f0\u96e3\u3092\u4f34\u3063\u305f\u5165\u9662\u30ec\u30d9\u30eb\u306e\u80ba\u708e\u306b\u306a\u308a\u307e\u3059\u3002<br>\u305d\u3057\u3066\u70b9\u6ef4\u3067\u5b89\u5168\u6027\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u7279\u4f8b\u627f\u8a8d\u85ac\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb(\u30d9\u30af\u30eb\u30ea\u30fc)\u6295\u4e0e\u3067\u526f\u4f5c\u7528\u4eba\u751f\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>&mdash; N (@ZInvester) <a href=\"https:\/\/twitter.com\/ZInvester\/status\/1607990507971706882?ref_src=twsrc%5Etfw\">December 28, 2022<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"ja\" dir=\"ltr\">\u7121\u63a5\u7a2e\u8005\u3067\u3082\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3092\u5b8c\u5168\u306b\u8a8d\u8b58\u3057\u3066\u5bfe\u7b56\u3057\u3066\u3044\u308b\u7387\u306f\u304b\u306a\u308a\u4f4e\u3044\u69d8\u5b50\u3002<br>\u305b\u3063\u304b\u304f\u6bd2\u30ef\u30af\u3092\u907f\u3051\u3066\u3082\u3001\u5468\u56f2\u304b\u3089\u306e\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u304c\u84c4\u7a4d\u3057\u305f\u3089\u547d\u306b\u95a2\u308f\u308b\u3002<br>\uff12\uff10\uff12\uff13\u5e74\u306f\u7121\u63a5\u7a2e\u8005\u306e\u7a81\u7136\u6b7b\u304c\u5831\u544a\u3055\u308c\u3066\u304f\u308b\u3068\u79c1\u306f\u4e88\u60f3\u3057\u3066\u308b\u3002 <a href=\"https:\/\/t.co\/fJO9wkaF3i\">https:\/\/t.co\/fJO9wkaF3i<\/a><\/p>&mdash; \u6cc9\u30a6\u30bf\u30de\u30ed\u3000izumi utamaro (@izumiutamaro) <a href=\"https:\/\/twitter.com\/izumiutamaro\/status\/1608024102379606020?ref_src=twsrc%5Etfw\">December 28, 2022<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"ja\" dir=\"ltr\">Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells<br>\u300c\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u4ecb\u3057\u305fmRNA\u3068\u30de\u30a4\u30af\u30edRNA\u306e\u8ee2\u9001\u306f\u3001\u7d30\u80de\u9593\u306e\u907a\u4f1d\u5b50\u4ea4\u63db\u306e\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308b\u300d<br><br> nature cell biology <br>Published: 07 May 2007<a href=\"https:\/\/t.co\/2ahNikzf3t\">https:\/\/t.co\/2ahNikzf3t<\/a><\/p>&mdash; kazuchan-cocone (@kazuchancocone) <a href=\"https:\/\/twitter.com\/kazuchancocone\/status\/1606850914434023424?ref_src=twsrc%5Etfw\">December 25, 2022<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"ja\" dir=\"ltr\">\u975e\u30b3\u30ed\u30ca\u306e2007\u5e74\u306e\u8ad6\u6587\u306a\u306e\u3067\u3001\u30a2\u30d6\u30b9\u30c8\u3057\u304b\u8aad\u3081\u306a\u3044\u304c\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306b\u306fmRNA\u3068\u30de\u30a4\u30af\u30edRNA\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u306emRNA\u306f\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3002<a href=\"https:\/\/t.co\/Y90XiqVD4M\">https:\/\/t.co\/Y90XiqVD4M<\/a><br>\u3000\u2193<br>mRNA\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u306e\u547c\u6c17\u3084\u6c57\u306b\u542b\u307e\u308c\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306bmRNA\u304c\u542b\u307e\u308c\u3001\u5468\u308a\u306e\u4eba\u306b\u4f1d\u64ad\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3059\u308b\u3053\u3068\u3092\u793a\u5506 <a href=\"https:\/\/t.co\/ukibjh1hCw\">https:\/\/t.co\/ukibjh1hCw<\/a><\/p>&mdash; J Sato (@j_sato) <a href=\"https:\/\/twitter.com\/j_sato\/status\/1607029630409805828?ref_src=twsrc%5Etfw\">December 25, 2022<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u7acb\u547d\u9928\u5927\u5b66\u751f\u547d\u79d1\u5b66\u90e8\u306e\u767d\u58c1\u606d\u5b50\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\u3001\u4e5d\u5dde\u5927\u5b66\u3001\u5927\u962a\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u819c\u305f\u3093\u3071\u304f\u8cea\u306e\u7279\u5b9a\u306e\u9818\u57df\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u304c\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\uff08\u4ee5\u4e0b\u3001\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\uff09\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u6c7a\u3081\u3066\u3044\u308b\u3053\u3068\u3092\u89e3\u660e\u3044\u305f\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u5b66\u8853\u8a8c\u300cJournal of Biological Chemistry\u300d\u3067\u767a\u8868\u3057\u3001\u63a1\u629e\u73872\uff05\u7a0b\u5ea6\u3067\u3042\u308bEditors&#8217; Picks\u306b\u3082\u9078\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\u306e\u9769\u65b0\u7684\u5148\u7aef\u7814\u7a76\u958b\u767a\u652f\u63f4\u4e8b\u696d\uff08AMED-CREST\uff09\u300c\u751f\u4f53\u6052\u5e38\u6027\u7dad\u6301\u30fb\u5909\u5bb9\u30fb\u7834\u7dbb\u6a5f\u69cb\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u7684\u7406\u89e3\u306b\u57fa\u3065\u304f\u6700\u9069\u533b\u7642\u5b9f\u73fe\u306e\u305f\u3081\u306e\u6280\u8853\u5275\u51fa\u300d\u7814\u7a76\u958b\u767a\u9818\u57df\u306b\u304a\u3051\u308b\u7814\u7a76\u958b\u767a\u8ab2\u984c\u300c\u7d30\u80de\u9593\u76f8\u4e92\u4f5c\u7528\u3068\u81d3\u5668\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u7834\u7dbb\u306b\u3088\u308b\u7d44\u7e54\u7dda\u7dad\u5316\u306e\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e\u3068\u533b\u5b66\u5fdc\u7528\u300d\uff08\u7814\u7a76\u958b\u767a\u4ee3\u8868\u8005\uff1a\u5c0f\u5ddd\u4f73\u5b8f\uff09\u306e\u4e00\u74b0\u3067\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u819c\u306b\u57cb\u3081\u8fbc\u307e\u308c\u305f\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3<sup>*1<\/sup>\u3092\u5207\u308a\u96e2\u3059\u300c\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u300d\u306f\u3001\u5207\u65ad\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u305d\u308c\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u7d30\u80de\u306e\u6a5f\u80fd\u3082\u5909\u63db\u3059\u308b\u5f71\u97ff\u529b\u306e\u5f37\u3044\u5206\u5b50\u6a5f\u69cb\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u672c\u7814\u7a76\u3067\u306f\u3001\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306e\u819c\u8fd1\u508d\u306b\u300c\u8ca0\u306e\u96fb\u8377\u3092\u6301\u3064\u30a2\u30df\u30ce\u9178\u300d\u3092\u591a\u304f\u542b\u3080\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3092\u514d\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u304c\u95a2\u308f\u308b\u708e\u75c7\u6027\u75be\u60a3\u30fb\u304c\u3093\u30fb\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3068\u3044\u3063\u305f\u69d8\u3005\u306a\u75be\u60a3\u306e\u6cbb\u7642\u65b9\u6cd5\u306e\u958b\u767a\u306b\u7e4b\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u7d30\u80de\u819c\u306b\u306f\u69d8\u3005\u306a\u6a5f\u80fd\u3092\u6301\u3064\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u57cb\u3081\u8fbc\u307e\u308c\u3066\u304a\u308a\u3001\u57cb\u3081\u8fbc\u307e\u308c\u3066\u3044\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u7d30\u80de\u304c\u679c\u305f\u305b\u308b\u6a5f\u80fd\u3082\u7570\u306a\u308a\u307e\u3059\u3002\u767d\u58c1\u6559\u6388\u3089\u304c\u7814\u7a76\u306e\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306f\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u7d30\u80de\u5916\u306b\u9732\u51fa\u3057\u3066\u3044\u308b\u90e8\u5206\u3092\u5207\u308a\u96e2\u3059\u3068\u3044\u3046\u5206\u5b50\u6a5f\u69cb\u3067\u3042\u308a\uff08\u56f31\uff09\u3001\u7d30\u80de\u8868\u9762\u306b\u3042\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d1\u30fc\u30c8\u30ea\u30fc\u3092\u5909\u3048\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u6a5f\u80fd\u3082\u5909\u3048\u3066\u3057\u307e\u3046\u3001\u5f37\u3044\u5f71\u97ff\u529b\u3092\u6301\u3063\u305f\u6a5f\u69cb\u3067\u3059\u3002\u307e\u305f\u708e\u75c7\u3092\u60f9\u8d77\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u7d30\u80de\u5897\u6b96\u3092\u4fc3\u3059\u5897\u6b96\u56e0\u5b50\u306b\u306f\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u4f5c\u3089\u308c\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3055\u308c\u3066\u521d\u3081\u3066\u5168\u8eab\u6027\u306b\u4f5c\u7528\u3059\u308b\u3082\u306e\u3082\u591a\u304f\u3001\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306f\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u6839\u5e79\u3092\u652f\u3048\u3066\u3044\u307e\u3059\u3002\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306f\u819c\u306b\u57cb\u3081\u8fbc\u307e\u308c\u305f\u5207\u65ad\u9175\u7d20<sup>*2<\/sup>\uff08\u56f31\u3001\u30cf\u30b5\u30df\uff09\u306b\u3088\u3063\u3066\u62c5\u308f\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u9175\u7d20\u306b\u306f\u7279\u5b9a\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u8a8d\u8b58\u3057\u3066\u5207\u65ad\u3059\u308b\u3068\u3044\u3063\u305f\u6027\u8cea\u306f\u306a\u304f\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u9650\u3089\u308c\u305f\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u304c\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3055\u308c\u308b\u306e\u304b\u306f\u307b\u3068\u3093\u3069\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><span class=\"swl-marker mark_orange\">\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3055\u308c\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u708e\u75c7\u306e\u60f9\u8d77\u3084\u304c\u3093\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u539f\u56e0\u3068\u306a\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3082\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3055\u308c\u8133\u306b\u84c4\u7a4d\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u304c\u3069\u3046\u3044\u3046\u6642\u306b\u8d77\u3053\u3063\u3066\u3001\u3069\u3046\u3044\u3046\u6642\u306b\u8d77\u3053\u3089\u306a\u3044\u306e\u304b\u3001\u3068\u3044\u3046\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3053\u308c\u3089\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u65b9\u6cd5\u304c\u69cb\u7bc9\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u7279\u306b\u3001\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u9175\u7d20\u304c\u8ca0\u306e\u96fb\u8377\u3092\u5acc\u3046\u3068\u3044\u3046\u4eca\u56de\u306e\u767a\u898b\u306f\u3001\u4f55\u3089\u304b\u306e\u65b9\u6cd5\u3067\u7d30\u80de\u8868\u9762\u306b\u8ca0\u306e\u96fb\u8377\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3067\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3092\u6291\u3048\u3089\u308c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u731b\u5a01\u3092\u596e\u3063\u3066\u3044\u308b\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3082\u3001\u5168\u8eab\u6027\u306e\u708e\u75c7\u53cd\u5fdc\u306e\u66b4\u8d70\u304c\u91cd\u7be4\u5316\u306e\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306e\u963b\u5bb3\u65b9\u6cd5\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u3067\u69d8\u3005\u306a\u75be\u60a3\u306e\u6cbb\u7642\u65b9\u6cd5\u306e\u69cb\u7bc9\u306b\u8ca2\u732e\u3067\u304d\u308c\u3070\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<cite>https:\/\/www.amed.go.jp\/news\/seika\/kenkyu\/20200721-01.html<\/cite><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306f\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u305d\u306e\u3082\u306e?<\/h2>\n\n\n\n<div class=\"wp-block-group is-style-big_icon_memo\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306f\u30d5\u30a1\u30a4\u30b6\u30fc\u306e\u30ef\u30af\u30c1\u30f3\u306e\u8aac\u660e\u8cc7\u6599\u306a\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u306f\u4eba\u4f53\u3067\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3092\u57f9\u990a\u3057\u3066\u3044\u308b\u3063\u3066\u3053\u3068\u3067\u3059\u3088\u306d\uff1f\u4e0d\u6d3b\u6027\u5316\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u3092\u3042\u3048\u3066\u5165\u308c\u3066\u6297\u4f53\u3092\u4f5c\u308b\u4eca\u307e\u3067\u306e\u30ef\u30af\u30c1\u30f3\u3068\u306f\u9055\u3044\u3001\u4eba\u4f53\u304c\u30a6\u30a4\u30eb\u30b9\u6e90\u3068\u306a\u308b\u3063\u3066&#8230;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3093\u306a\u3093\u666e\u901a\u306b\u4ed6\u4eba\u306b\u611f\u67d3\u3057\u307e\u3059\u3088\u306d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u308b\u307b\u3069\u305d\u308c\u304c\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306e\u6b63\u4f53\u304b&#8230;<\/p>\n<\/div><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><span class=\"swl-marker mark_orange\">\u6838\u9178\u30ef\u30af\u30c1\u30f3\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u30ef\u30af\u30c1\u30f3\u540c\u69d8\u306b\u3001\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u306e\u92f3\u578b\u3068\u306a\u308b\u907a\u4f1d\u5b50\u3092\u6295\u4e0e\u3057\u3001\u907a\u4f1d\u5b50\u304c\u53d6\u308a\u8fbc\u307e\u308c\u305f\u7d30\u80de(\u5de5\u5834)\u306b\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u3092\u7523\u751f\u3055\u305b\u308b \u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/span>DNA\u30ef\u30af\u30c1\u30f3\u3068mRNA\u30ef\u30af\u30c1\u30f3\u306b\u306f\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<span class=\"swl-marker mark_orange\">DNA\u30ef\u30af\u30c1\u30f3\u306f\u3001\u6297\u539f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u92f3\u578b\u3068\u306a\u308bDNA\u304c\u6838\u306b\u5165\u308a\u3001\u6838\u5185\u3067mRNA(\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA)\u306b\u8ee2\u5199\u3055\u308c\u307e\u3059\u3002mRNA\u306f\u6838\u306e\u5916\u306b\u51fa\u3066\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u7ffb\u8a33\u3055\u308c\u3066\u6297\u539f\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7523\u751f\u3055\u308c\u307e\u3059\u3002 \u4e00\u65b9\u3001mRNA\u30ef\u30af\u30c1\u30f3\u306emRNA\u306f\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u7ffb\u8a33\u3055\u308c\u3066\u6297\u539f\u304c\u7523\u751f\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1-2. mRNA<\/strong><strong>\u30ef\u30af\u30c1\u30f3<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><img decoding=\"async\" src=\"blob:https:\/\/blackfire.work\/91725f76-4c50-4aab-85ff-465e762f1f31\" alt=\"page3image3716482112\" width=\"902.090000\" height=\"2.260000\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">mRNA\u30ef\u30af\u30c1\u30f3\u306f\u3001\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u308a\u30a6\u30a4\u30eb\u30b9\u306e\u4e00\u90e8(\u6297\u539f)\u3092\u7523\u751f\u3057\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1&nbsp;mRNA\u30ef\u30af\u30c1\u30f3\u306f\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u306e\u92f3\u578b\u3067\u3042\u308a(COVID-19 mRNA\u30ef\u30af\u30c1\u30f3\u306e\u5834\u5408\u306f\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u90e8\u307e\u305f\u306f\u5168\u3066\u3092\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u3068\u3057\u3066\u7523\u751f\u3059\u308b\u92f3\u578b \u3067\u3059)\u3001\u8102\u8cea\u306e\u819c\u306b\u5305\u307e\u308c\u3066\u6a19\u7684\u7d30\u80de\u3078\u904b\u3070\u308c\u307e\u3059\u3002 \u3053\u306e\u8102\u8cea\u306e\u819c\u306fmRNA\u3092\u4fdd\u8b77\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001mRNA\u3092\u7d30\u80de\u306e\u4e2d\u306b\u904b\u3073\u5165\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2 \u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305fmRNA\u306f\u7d30\u80de\u8cea\u306b\u653e\u51fa\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3&nbsp;mRNA\u304c\u7d30\u80de\u8cea\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3068\u3001\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u7523\u751f\u5de5\u5834\u3067\u3042\u308b\u30ea\u30dc\u30bd\u30fc\u30e0\u304cmRNA\u3092\u8a2d\u8a08\u56f3\u3068\u3057\u3066\u7528\u3044\u3066\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u3092\u7523\u751f\u3057\u307e\u3059\u3002 \u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u7ffb\u8a33\u3068\u547c\u3070\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4 \u30a6\u30a4\u30eb\u30b9\u6297\u539f\u306f\u7d30\u80de\u5185\u3067\u904b\u3070\u308c\u3066\u3001\u7d30\u80de\u8868\u9762\u306b\u6297\u539f\u3068\u3057\u3066\u63d0\u793a\u3055\u308c\u307e\u3059\u3002\u6297\u539f\u306b\u5bfe\u3057\u3066\u6db2\u6027\u514d\u75ab(\u6297\u4f53\u7523\u751f)\u304a\u3088\u3073\u7d30\u80de\u6027\u514d\u75ab(T\u7d30\u80de)\u306e\u4e21\u65b9\u306e\u514d\u75ab \u5fdc\u7b54\u3092\u8d77\u3053\u3057\u307e\u3059\u3002\u5c0e\u5165\u3055\u308c\u305fmRNA\u306f\u81ea\u7136\u306b\u5206\u89e3\u3055\u308c\u3001\u4eba\u306e\u8eab\u4f53\u306e\u907a\u4f1d\u5b50\u306b\u306f\u7d44\u307f\u8fbc\u307e\u308c\u307e\u305b\u3093\u3002<\/p>\n<cite>https:\/\/www.pfizer-covid19-vaccine.jp\/mRNA\u30ef\u30af\u30c1\u30f3\u306b\u3064\u3044\u3066.pdf<\/cite><\/blockquote>\n\n\n\n<p class=\"is-style-big_icon_hatena wp-block-paragraph\">\u3064\u307e\u308a\u4f53\u5185\u3067\u30a6\u30a4\u30eb\u30b9\u3092\u57f9\u990a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6297\u4f53\u3092\u4f5c\u308d\u3046\u3068\u3057\u305f\u306e\u304cmRNA\u30ef\u30af\u30c1\u30f3\u305d\u3057\u3066\u4eba\u304c\u57f9\u990a\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u304c\u4ed6\u306e\u4eba\u306b\u611f\u67d3\u3057\u305f\u72b6\u614b\u304c\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u611f\u3058\u304b\u306a\uff1f<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30d5\u30a1\u30a4\u30b6\u30fc\u3082\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306b\u3064\u3044\u3066\u306f\u8a8d\u3081\u3066\u3044\u308b<\/h2>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"ja\" dir=\"ltr\">\u3010\u62e1\u6563\u3057\u3066\u304f\u3060\u3055\u3044\u3011\u30d5\u30a1\u30a4\u30b6\u30fc\u306f\u611f\u67d3\u9632\u6b62\u52b9\u679c\u3092\u30c6\u30b9\u30c8\u3057\u3066\u3044\u306a\u3044\u3000\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306f\u628a\u63e1\u3057\u3066\u3044\u305f <a href=\"https:\/\/t.co\/NOyJ7P2ewa\">pic.twitter.com\/NOyJ7P2ewa<\/a><\/p>&mdash; \u3089\u3089\u30cb\u30e3\u30f3\u266a\ud83c\uddef\ud83c\uddf5\u826f\u3044\u6642\u4ee3\u304c\u6765\u308b\u3053\u3068\u3092\ud83d\ude4f (@SetoHighway) <a href=\"https:\/\/twitter.com\/SetoHighway\/status\/1609873114212749314?ref_src=twsrc%5Etfw\">January 2, 2023<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"ja\" dir=\"ltr\">\u539a\u52b4\u7701\u306e\u30d5\u30a1\u30a4\u30b6\u30fc\u306e\u308a\u5f01\u8cc7\u6599\u306b\u3082\u653e\u5c04\u80fd\u306e\u3053\u3068\u66f8\u3044\u3066\u3042\u308b\u3002\u30ef\u30af\u30c1\u30f3\u6253\u3063\u3066\u3067\u653e\u5c04\u80fd\u691c\u51fa\u3055\u308c\u308b\u3063\u3066\u3069\u3086\u3053\u3068\u2049\ufe0f<br>\u3060\u304b\u3089\u3001\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3068\u304b\u3042\u308b\u306e\u304b\u3002\u30d2\u30d0\u30af\u2026\ud83e\udd72<br>\u63a5\u7a2e\u3059\u308b\u5ea6\u306b\u30c8\u30ea\u30c1\u30a6\u30e0\u304c\u84c4\u7a4d\u3059\u308b\u2026\u764c\u304c\u52a0\u901f\u3059\u308b\u7406\u7531\u3082\u3053\u308c\u3067\u7d0d\u5f97\u3002 <a href=\"https:\/\/t.co\/lWENLqBcvU\">pic.twitter.com\/lWENLqBcvU<\/a><\/p>&mdash; Miso soup (@dgajugmpjtgwpd) <a href=\"https:\/\/twitter.com\/dgajugmpjtgwpd\/status\/1607697747003723776?ref_src=twsrc%5Etfw\">December 27, 2022<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"ja\" dir=\"ltr\">\u4eca\u6642\u307e\u3060\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3092\u8a8d\u3081\u3089\u308c\u306a\u3044\u65b9\u304c\u3044\u308b\u306e\u3067\u3001\u4eca\u66f4\u30d5\u30a1\u30a4\u30b6\u30fc\u6587\u66f8\u3092\u8a73\u3057\u304f\u8aac\u660e\u3057\u306a\u304d\u3083\u3044\u3051\u306a\u3044\u3002<br> <a href=\"https:\/\/t.co\/lUwLA5r6M1\">https:\/\/t.co\/lUwLA5r6M1<\/a><\/p>&mdash; \u5c0f\u6885 (@CGioWwsugjU2dJp) <a href=\"https:\/\/twitter.com\/CGioWwsugjU2dJp\/status\/1608794567301820419?ref_src=twsrc%5Etfw\">December 30, 2022<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u30ef\u30af\u30c1\u30f3\u306e\u3084\u3070\u3044\u3068\u3053\u306f\u4ed6\u306e\u30a6\u30a4\u30eb\u30b9\u3084\u75c5\u539f\u4f53\u307e\u3067\u6d3b\u6027\u5316\u3057\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3053\u3068<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">2021\u5e74\u306b\u5165\u3063\u3066\u304b\u3089\u3001\u76ae\u819a\u79d1\u3067\u306f\u5e2f\u72b6\u75b1\u75b9\u306b\u304b\u304b\u308b\u4eba\u304c\u591a\u304f\u306a\u3063\u3066\u3044\u308b\u3068SNS\u3067\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u539f\u56e0\u306f\u30b3\u30ed\u30ca\u767a\u75c7\u3067\u4f53\u529b\u304c\u843d\u3061\u308b\u3053\u3068\u306f\u5341\u5206\u306b\u8003\u3048\u3089\u308c\u307e\u3059\u3057\u3001\u30b3\u30ed\u30ca\u798d\u3067\u30b9\u30c8\u30ec\u30b9\u304c\u5897\u3048\u305f\u4eba\u306f\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u5916\u51fa\u5236\u9650\u3084\u5728\u5b85\u52e4\u52d9\u3067\u904b\u52d5\u91cf\u304c\u6e1b\u308c\u3070\u4f53\u3082\u5f31\u308a\u62b5\u6297\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u307e\u305f\u5b50\u4f9b\u3084\u5b6b\u3068\u306e\u63a5\u89e6\u3092\u907f\u3051\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u6c34\u75d8\u30a6\u30a4\u30eb\u30b9\u3068\u306e\u63a5\u89e6\u3082\u306a\u304f\u306a\u308a\u30d6\u30fc\u30b9\u30bf\u30fc\u52b9\u679c\u304c\u306a\u304f\u306a\u308a\u3001\u305d\u308c\u3089\u306e\u7d50\u679c\u3068\u3057\u3066\u3001\u5e2f\u72b6\u75b1\u75b9\u304c\u5897\u52a0\u3057\u3066\u3044\u3066\u3082\u4e0d\u601d\u8b70\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3068\u3053\u308d\u3067\u3001<strong><span class=\"swl-marker mark_orange\">\u6d77\u5916\u304b\u3089\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u3001\u307b\u3093\u306e\u308f\u305a\u304b\u5e2f\u72b6\u75b1\u75b9\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u304c\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u30b9\u30da\u30a4\u30f3\u3067\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u76ae\u819a\u53cd\u5fdc\u3092\u8d77\u3053\u3057\u305f\u75c7\u4f8b\u306e\u5206\u6790\u7d50\u679c\u3067\u3059\u3002\u60a3\u8005\u6570\u306f391\u4eba\u3067\u3001\u4f7f\u7528\u3057\u305f\u30ef\u30af\u30c1\u30f3\u306f\u30d5\u30a1\u30a4\u30b6\u30fc\u88fd\u304c40.2\uff05\u3001\u30e2\u30c7\u30eb\u30ca\u88fd\u304c36.3\uff05\u3001\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u88fd\u304c23.5\uff05\u3067\u3057\u305f\u3002\u305d\u306e\u3046\u306113.8%\u306b\u6c34\u75d8\u5e2f\u72b6\u75b1\u75b9\u30a6\u30a4\u30eb\u30b9\u306e\u518d\u6d3b\u6027\u5316\u3084\u3001\u5358\u7d14\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u306e\u518d\u71c3\u304c\u8a8d\u3081\u3089\u308c\u305f\u305d\u3046\u3067\u3059<sup>\uff11\uff09<\/sup>\u3002\u5076\u7136\u306e\u767a\u75c7\u3068\u3057\u3066\u306f\u3084\u3084\u983b\u5ea6\u304c\u9ad8\u3044\u3088\u3046\u3067\u3059\u3002van Dam\u3089\u306f\u30d5\u30a1\u30a4\u30b6\u30fc\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u5e2f\u72b6\u75b1\u75b9\u3092\u767a\u75c7\u3057\u305f\uff12\u4f8b\u3092\u5831\u544a\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u539f\u56e0\u3068\u3057\u3066\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u8d77\u3053\u308b\u4e00\u904e\u6027\u306e<span class=\"swl-fz u-fz-l\">\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11<\/span>\u3067\u3042\u308b\u3068\u8aac\u660e\u3057\u3066\u3044\u307e\u3059<sup>\uff12\uff09<\/sup>\u3002\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3057\u305f\u306e\u3061\u306b70%\u306e\u4eba\u306b\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u304c\u8d77\u3053\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u306f\u5f53\u7136\u3042\u308b\u3068\u8ff0\u3079\u3066\u304a\u308a\u3001\u5b9f\u969b\u305d\u306e\u3088\u3046\u306a\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3068\u3059\u308b\u5831\u544a\u3082\u3042\u308a\u307e\u3059<sup>\uff13\uff09<\/sup>\u3002\u307e\u305f\u3001\u305d\u306e\u8003\u5bdf\u306e\u4e2d\u3067\u3001\u6b27\u5ddeEudraVigilance\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u3088\u308b\u3068\u3001\u30d5\u30a1\u30a4\u30b6\u30fc\u88fd\u30674103\u4f8b\uff081.3%\uff09\u3001\u30e2\u30c7\u30eb\u30ca\u88fd\u3067590\u4f8b\uff080.7%\uff09\u3001\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u88fd\u30672143\u4f8b\uff080.6%\uff09\u3001\u30e4\u30f3\u30bb\u30f3\u88fd\u3067 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